monocyte expression of toll-like receptor-4 in patients with stable angina undergoing percutanoeus coronary intervention

Authors

bahador bagheri

department of pharmacology, faculty of pharmacy bahram sohrabi

shahid madani heart hospital aliakbar movassaghpur

hematology research centre siminozar mashayekhi

department of clinical pharmacy, faculty of pharmacy afagh garjani

abstract

background: toll like receptors (tlrs) are well recognized players in inflammatory conditions. among them tlr-4 is involved in chronic inflammatory processes such as formation of atherosclerotic plaques. objective: the present study was aimed to examine the effects of percutanoeus coronary intervention (pci) as a revascularization method on monocyte expression of htlr-4 and on the serum levels of two proinflammatory cytokines (tnf-α and il-1β). methods: blood samples were obtained from 41 patients with stable angina who were candidates for pci. the samples were collected immediately before and 2h and 4h after pci. the expression of htlr-4 on cd14+ monocytes and the serum levels of tnf-α and il-1β were measured using flowcytometry and elisa techniques, respectively. results: by comparing the frequency of circulating htlr-4+/cd14+ monocytes at different time points, it was observed that pci procedure up regulates the monocyte expression of htlr-4 (p

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Journal title:
iranian journal of immunology

جلد ۹، شماره ۳، صفحات ۱۴۹-۱۵۸

Keywords
[ ' i n f l a m m a t i o n ' , ' p e r c u t a n o e u s c o r o n a r y i n t e r v e n t i o n ' , ' t o l l l i k e r e c e p t o r ' , 4 , ' s t a b l e a n g i n a ' ]

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